منابع مشابه
Raising expectations for subunit vaccine.
Multidose regimens are recommended for all prophylactic subunit vaccines. Recent findings from clinical trials of an human papillomavirus virus-like particle vaccine suggest that it may be possible to develop effective single-dose subunit vaccines. The broad implications of these findings are discussed, and the importance of antigen structure and adjuvant in achieving this goal is considered. I...
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PURPOSE To elucidate and discuss the role of IL-35 in immunity to parasitic and bacterial infections as well as in autoimmunity in terms of its anti-inflammatory properties, we highlight significant findings on this novel member of the IL-12 family. METHODS Studies using genetically deficient mice have greatly enhanced our understanding of the biology of IL-35. On the basis of data derived fr...
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F ive years ago there were little more than 200 known microRNAs (miRNAs) — small regulatory nucleic acids that bind to complementary sites on mRNAs and prevent their translation into protein. Today, that number has swelled to more than 700 and counting. The explosion in knowledge about these small, noncoding RNAs, which appear to be evolutionarily ancient but were discovered less than two decad...
متن کاملIn silico analysis of Omp25 and BLS Brucella melitensis antigens for designing subunit vaccine
Brucellosis is a well-known infection in domestic animals which caused by Brucella bacterium. Due toserious economic and medical consequences of this disease, various efforts have been made to prevent theinfection through the use of recombinant vaccines based on Brucella outer membrane protein (OMP)antigens. The objectives of the present study were cloning, sequencing and epitope prediction of ...
متن کاملRaising Expectations in GDA Agents Acting in Dynamic Environments
Goal-driven autonomy (GDA) agents reason about goals while introspectively examining if their course of action matches their expectations. Many GDA agents adopt a hierarchical planning model to generate plans but limit reasoning with expectations to individual actions or projecting the expected state. In this paper we present a relaxation of this limitation. Taking advantage of hierarchical pla...
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ژورنال
عنوان ژورنال: The Journal of Infectious Diseases
سال: 2014
ISSN: 0022-1899,1537-6613
DOI: 10.1093/infdis/jiu648